Πλοήγηση ανά Συγγραφέα "Santos, M."
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Do alcohol-metabolizing enzyme gene polymorphisms increase the risk of alcoholism and alcoholic liver disease?
Zintzaras, E.; Stefanidis, I.; Santos, M.; Vidal, F. (2006)Case-control studies that have investigated the association between alcoholism and alcohol-induced liver damage and the ADH2, ADH3, CYP2E1, and ADLH2 polymorphisms have reported controversial or inconclusive results. Thus, ... -
Estimating the mode of inheritance in genetic association studies of qualitative traits based on the degree of dominance index
Zintzaras, E.; Santos, M. (2011)Background: The biological justification for the choice of the genetic mode in genetic association studies (GAS) is seldom available. Then, the mode of inheritance is approximated by investigating a number of non-orthogonal ... -
Performance of MAX Test and Degree of Dominance Index in Predicting the Mode of Inheritance
Zintzaras, E.; Santos, M. (2012)We evaluate power performance to detect the correct mode of inheritance in gene-disease associations of two different approaches: the MAX test and the degree of dominance index or h-index. The MAX test is a special case ... -
Recombination in primeval genomes: A step forward but still a long leap from maintaining a sizable genome
Santos, M.; Zintzaras, E.; Szathmary, E. (2004)A stubborn question in early molecular evolution is how to sustain the "minimum" informational length required for the basic features of life with a putative low-copying fidelity RNA polymerase ribozyme. Proposals to ... -
Selfishness versus functional cooperation in a stochastic protocell model
Zintzaras, E.; Santos, M.; Szathmary, E. (2010)How to design an evolvable artificial system capable to Increase in complexity? Although Darwin s theory of evolution by natural selection obviously offers a firm foundation little hope of success seems to be expected from ...